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Scientific Studies

Scientific Studies

A variety of studies and research have been completed on Sucralose, the sweetening ingredient in SPLENDA® Sweetener Products.

Safety Studies

A review of an extensive body of evidence concludes that Sucralose, the sweetening ingredient in SPLENDA® Sweetener Products, is safe for use by the entire population without exception

An Overview Of The Safety Of Sucralose
Grotz VL, Munroe IC. Regulatory Toxicology and Pharmocology. 2009;55:1-5 A review of the extensive body of evidence that supports the safety of Sucralose. The results of an independent review of a recent study investigating the safety of a Sucralose-mixture retail product, SPLENDA® Low Calorie Sweetener, Granulated, are also discussed. The review covers;

  • Physiochemical properties and pharmokinetics
  • Acute exposure
  • Long-term safety
  • Clinical studies
  • Estimated daily intake and Sucralose mixtures

Diabetes Studies

Several scientific studies have been completed focusing on the use of Sucralose in patients with diabetes.

Glycemic Effect of a single high oral dose of the novel sweetener Sucralose in patients with diabetes
Mezitis NHE, Maggio CA, Koch P, et al. Diabetes Care. 1996;19(9):1004-1005. This randomised, double-blind, placebo-controlled, crossover study was designed to assess the effect of a single oral high dose of Sucralose on short-term glycemic control in patients with insulin-dependent diabetes mellitus (T1DM) or non-insulin-dependent diabetes mellitus (T2DM).
Lack of effect of Sucralose on glucose homeostasis in subjects with type 2 diabetes
Grotz VL, Henry RR, McGill JB, et al. J Am Diet Assoc. 2003;103(12): 1607-1612. This double-blind, randomised, placebo-controlled, parallel-group, multicenter study evaluated the effects of high daily doses of Sucralose in patients with type 2 diabetes over a period of 3 months.

Dental Studies

Dental Considerations in Sucralose Use.

Mandel ID, Grotz VL. J Clin Dentistry. 2002;13(3):116-118. A discussion paper that presents the results of a number of studies that assessed whether Sucralose has cariogenic potential. Conclusion: When used to replace sugar, both Sucralose and the tested Sucralose-based sweeteners may be useful in the dietary management of caries.

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